最近在看关于脂质体的论文,下面是其中一篇“齐墩果酸长循环脂质体的制备”,仔细一看,中文还说得过去,摘要翻译就不好说了,呵呵。典型的中式英语啊,呵呵。
摘要:目的:研究齐墩果酸长循环脂质体的制备方法。方法:用薄膜法制备齐墩果酸长循环脂质体,并采用L9(34)正交试验对其进行了优化。采用HPLC法测定并计算在不同水平和因素下齐墩果酸长循环脂质体的包封率和载药量,以包封率为指标考察各处方因素对脂质体的影响。结果:优化后的脂质体平均包封率为98.25%,平均载药量为11.85%。结论:用薄膜法可制备包封率高的齐墩果酸长循环脂质体,包封率重现性好,简便易行。
关键词:齐墩果酸;长循环脂质体;薄膜法;正交试验;包封率
Preparation of Oleanolic acid long-circulating liposome
Abstract:Objective: To study the Oleanolic acid long-circulating liposome preparation method. Methods: Oleanolic acid long-circulating liposome are prepare by Films Act ,and use L9(34)of orthogonal test to optimize them. the encapsulation efficiency and drug loading of Oleanolic acid long-circulating liposome are determination by HPLC, at different levels and factors.Encapsulation efficiency as an index to study the prescription on the effects of liposomes.Result:The average of encapsulation efficiency of the liposome which have been optimized are 98.25%,and the average of drug loading was 11.85%.Conclusion: The Film Act can preparation Oleanolic acid long-circulating liposome which are high rate of drug loading.Its known that encapsulation efficiency of the Oleanolic acid long-circulating liposome are well reproducibility and the method is easy to use.
Keywords:leanolic acid;long-circulating liposome;Films Act;orthogonal experiments;the encapsulation efficiency