2012-5-2 11:45

Perfluoroalkyl Acids in the Atlantic and Canadian Arctic Oceans

Environmental Science & Technology, Volume 0, Issue ja, Articles ASAP (As Soon As Publishable).
Jonathan Philip Benskin et al | RSS

2012-5-2 11:15

Selenium Reduces the Retention of Methyl Mercury in the Brown Shrimp Crangon crangon

Environmental Science & Technology, Volume 0, Issue ja, Articles ASAP (As Soon As Publishable).
Poul Bjerregaard et al | RSS

2012-5-2 10:39

Efficient Near-infrared Emitting Cationic Iridium Complexes as Dopants for OLEDs with Small Efficiency Roll-off

The Journal of Physical Chemistry C, Volume 0, Issue ja, Articles ASAP (As Soon As Publishable).
Ran Tao et al | RSS

2012-5-2 10:15

Enhanced Prostate Cancer Targeting by Modified Protease Sensitive Photosensitizer Prodrugs

Molecular Pharmaceutics, Volume 0, Issue ja, Articles ASAP (As Soon As Publishable).
Maria Fernanda Zuluaga et al | RSS

2012-5-2 09:45

Efficient in vitro siRNA delivery and Intramuscular Gene Silencing using PEG-modified PAMAM Dendrimers

Molecular Pharmaceutics, Volume 0, Issue ja, Articles ASAP (As Soon As Publishable).
Yin Tang et al | RSS

2012-5-2 09:10

A Pilot-Scale Study of CO2 Capture by CaO based Sorbents in the Presence of Steam and SO2

Industrial & Engineering Chemistry Research, Volume 0, Issue ja, Articles ASAP (As Soon As Publishable).
Robert T Symonds et al | RSS

2012-5-1 18:55

Effect of Hypertrophic Cardiomyopathy-Linked Troponin C Mutations on the Response of Reconstituted Thin Filaments to Calcium upon Troponin I Phosphorylation

Biochemistry, Volume 51, Issue 17, Page 3614-3621, May 1, 2012.
Acchia N. J. Albury et al | RSS

2012-5-1 18:18

Intranasal delivery of biologics to the central nervous system

Publication year: 2012
Source:Advanced Drug Delivery Reviews, Volume 64, Issue 7

Jeffrey J. Lochhead, Robert G. Thorne

Treatment of central nervous system (CNS) diseases is very difficult due to the blood–brain barrier's (BBB) ability to severely restrict entry of all but small, non-polar compounds. Intranasal administration is a non-invasive method of drug delivery which may bypass the BBB to allow therapeutic substances direct access to the CNS. Intranasal delivery of large molecular weight biologics such as proteins, gene vectors, and stem cells is a potentially useful strategy to treat a variety of diseases/disorders of the CNS including stroke, Parkinson's disease, multiple sclerosis, Alzheimer's disease, epilepsy, and psychiatric disorders. Here we give an overview of relevant nasal anatomy and physiology and discuss the pathways and mechanisms likely involved in drug transport from the nasal epithelium to the CNS. Finally we review both pre-clinical and clinical studies involving intranasal delivery of biologics to the CNS.

Graphical Abstract

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ScienceDirect Publication: Advanced Drug Delivery Reviews | RSS

2012-5-1 18:18

Editorial Board

Publication year: 2012
Source:Advanced Drug Delivery Reviews, Volume 64, Issue 6








ScienceDirect Publication: Advanced Drug Delivery Reviews | RSS

2012-5-1 18:18

Polymeric nanoparticles for drug delivery to the central nervous system

Publication year: 2012
Source:Advanced Drug Delivery Reviews, Volume 64, Issue 7

Toral Patel, Jiangbing Zhou, Joseph M. Piepmeier, W. Mark Saltzman

The central nervous system (CNS) poses a unique challenge for drug delivery. The blood–brain barrier significantly hinders the passage of systemically delivered therapeutics and the brain extracellular matrix limits the distribution and longevity of locally delivered agents. Polymeric nanoparticles represent a promising solution to these problems. Over the past 40years, substantial research efforts have demonstrated that polymeric nanoparticles can be engineered for effective systemic and local delivery of therapeutics to the CNS. Moreover, many of the polymers used in nanoparticle fabrication are both biodegradable and biocompatible, thereby increasing the clinical utility of this strategy. Here, we review the major advances in the development of polymeric nanoparticles for drug delivery to the CNS.




ScienceDirect Publication: Advanced Drug Delivery Reviews | RSS
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